Intraepithelial carcinoma (Bowen disease) - Intraepithelial Carcinoma (Bowen Sykte)
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Typysk gefal: Intraepithelial Carcinoma (Bowen Sykte) (Intraepithelial carcinoma (Bowen disease)) kin ferkeard diagnostearre wurde as in lang duorjende, net‑jeukende eczeem.
relevance score : -100.0%
ReferencesBowen's disease (BD) is in soarte fan hûdkanker dat begjint yn 'e bûtenste laach fan' e hûd (epidermis). It komt faker foar by Kaukasiërs en komt faak foar yn gebieten dy't bleatsteld binne oan sinneljocht, mar it kin ek earder oars ferskine. BD ferskynt typysk as in inkele lesion. BD wurdt faak sjoen as in warskôgingsteken foar't in mear serieuze soarte fan hûdkanker ûntwikkelt. Om BD te diagnostearjen, fertrouwe dokters gewoanlik op it ûndersykjen fan weefselmonsters ûnder in mikroskoop (biopsy).
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease beinvloedt meast blanke persoanen âlder as 60 jier. Wichtige risikofaktoaren omfetsje lange‑termyn bleatstelling oan de sinne, in ferswakke immúnsysteem, bleatstelling oan arseen, en HPV‑ynfeksje fan 'e hûd. HPV‑stammen 16, 18, 34 en 48 binne keppele oan de sykte Bowen yn genitale gebieten. De belutsenheid fan HPV yn net‑genitale gefallen is minder dúdlik.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
It ferskynt meastentiids as in erythemateus, skaalich of krústich gebiet op elke lokaasje fan it lichem. De meast foarkommende lokaasje is de ûnderste skonken.
It kin genêzen wurde mei ferskate behannelingsopsjes, lykas kryoterapy, curettage, cautery, fotodynamyske terapy, of útsnijing fan de lesion.
○ Diagnose en behanneling
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy